早期乳腺癌新辅助化疗联合保乳术治疗临床效果研究.docVIP

早期乳腺癌新辅助化疗联合保乳术治疗临床效果研究[摘要] 目的：探讨环磷酰胺（CTX）+吡柔比星（THP）+氟尿嘧啶（FU）方案新辅助化疗后行乳腔镜保乳手术疗效及美容效果。方法：对2006年9月～2010年9月在本院行新辅助化疗联合保乳术治疗的30例早期乳腺癌患者的临床资料进行回顾性分析。结果：30例患者经治疗后客观有效率RR为93.3%，所有患者均存活，术后患者患侧乳房满意度好以上达到96.7%，部分患者出现不同程度骨髓抑制恶心、呕吐、脱发等不良反应，经处理后均可较好耐受。结论：早期乳腺癌采取新辅助化疗联合保乳术治疗，疗效显著，便于保乳并且美容效果好。 [关键词] 早期乳腺癌；新辅助化疗；保乳术；临床效果 [中图分类号] R737.9 [文献标识码]A[文章编号]1674-4721（2011）04（a）-030-02 Neoadjuvant chemotherapy in early breast cancer breast-conserving surgery for analysis of clinical effects CHEN Jishan Department of Pathology, Yongzhou Vocational College Hospital, Hunan Province, Yongzhou 425000, China [Abstract] Objective: To investigate the cyclophosphamide (CTX) + pirarubicin (THP) + fluorouracil (FU) neoadjuvant chemotherapy underwent endoscopic breast conserving surgery and cosmetic results. Methods: From September 2006 to September 2010 in our hospital neoadjuvant chemotherapy and breast-conserving surgery for early breast cancer patients 30 patients were retrospectively analyzed. Results: 30 patients with objective response rate after treatment RR was 93.3%, all patients were alive after a good patient satisfaction more than ipsilateral breast 96.7%, in some patients with varying degrees of bone marrow suppression, nausea, vomiting, hair loss and other adverse reactions , after treatment may be better tolerated. Conclusion: Early breast cancer to neoadjuvant chemotherapy and breast-conserving treatment, a significant effect, easy and cosmetic results of breast-conserving good. [Key words] With early breast cancer; Neoadjuvant chemotherapy; Conserving surgery; Clinical effect 乳腺癌是女性最常见的恶性肿瘤且发病率逐年上升。目前将肿瘤直径小于5 cm，无同侧腋窝淋巴结受累或伴有同侧活动淋巴结的乳腺癌称为早期乳腺癌[1]，这其中包括TNM分期T1~2、N0~1以及临床Ⅰ、Ⅱ期，随着对乳腺癌生物学特性及其发病机制的深入认识，治疗措施的不断完善和人们对美学及高生活质量的追求，保乳手术已成为早期乳腺癌治疗的重要形式，而新辅助化疗为保乳手术创造了更有利的条件。本院2006年10月~2010年10月起对30例早期乳腺癌患者进行了新辅助化疗联合乳腔镜保留乳房手术，取得了较好效果。 1 资料与方法 1.1 一般资料 本组30例早期乳腺癌患者，年龄25～56岁，平均46.1岁。病史6 d～4个月，平均20 d；绝经前25例，绝经后5例；肿瘤位于左乳19例，右乳11例；外上象限16例，外下象限11例，内上象限3例。肿块直径1～4 cm，肿瘤边缘距乳晕