曲美他嗪联合美托洛尔治疗老年慢性心力衰竭疗效观察.docVIP

曲美他嗪联合美托洛尔治疗老年慢性心力衰竭疗效观察[摘要] 目的：观察曲美他嗪联合美托洛尔治疗老年慢性充血性心力衰竭（CHF）的临床疗效。方法：选择老年CHF患者68例，随机分为对照组（34例）和治疗组（34例）。两组均给予洋地黄制剂、利尿剂、血管扩张剂、血管紧张素转换酶抑制剂（ACEI）等常规治疗。治疗组在常规治疗的基础上，加用曲美他嗪和美托洛尔，疗程为6个月，比较两组疗效。结果：治疗组31例有效，心功能改善总有效率为91.18%，对照组24例有效，总有效率为70.59%，两组间比较有显著性差异（P＜0.05）。治疗组治疗前后心功能各项指标均有显著改善（P＜0.05）。结论：曲美他嗪和美托洛尔联合应用能有效改善老年CHF患者的心功能，降低死亡率。 [关键词] 慢性充血性心力衰竭；曲美他嗪；美托洛尔；老年人 [中图分类号] R541.6[文献标识码]B [文章编号]1673-7210（2010）11（b）-058－０2 The efficacy of Trimetazidine combined with Metoprolol in the treatment of chronic congestive heart failure for the old patients QU Zhe (Department of Elderly Medicine, Fengtian Hospital Affiliated to Shenyang Medical College, Shenyang 110024, China) [Abstract] Objective: To observe the clinical effects of using Trimetazidine combined with Metoprolol on the basis of routine treatment of chronic congestive heart failure (CHF) for the old patients. Methods: 68 old chronic CHF patients were collected and randomly divided into control group (34 cases) and treatment group (34 cases). Two groups were given digitalis preparations, diuretics, vasodilators and angiotensin converting enzyme inhibitors. Added Trimetazidine and Metoprolol on the basis of routine treatment in treatment group, a course of 6 months, two groups were compared. Results: 31 patients showed improved symptoms in treatment group with the total effective rate of 91.18%; 24 patients showed improved symptoms in control group with the total effective rate of 70.59%, there are significant differences between the two groups (P＜0.05). The indicators of cardiac function before and after treatment had the significant improvement in treatment group (P＜0.05). Conclusion: Trimetazidine combined with Metoprolol can improve the heart function of the old patients with CHF and reduce the death rate. [Key words] Chronic congestive heart failure; Trimetazidine; Metoprolol; Elderly patients 慢性充血性心力衰竭（chronic congestive heart failure，CHF）是老年各种心血管疾病的终末阶段，也是老年心脏病患者最主要的死亡原因。为寻求有效的治疗方法，降低死亡率，我们在常规