程序性细胞死亡-1-程序性细胞死亡配体-1信号途径和其对口腔慢性疾病作用.docVIP

程序性细胞死亡-1/程序性细胞死亡配体-1信号途径和其对口腔慢性疾病作用[摘要]程序性细胞死亡-1（PD-1）/程序性细胞死亡配体-1（PD-L1）作为B7-CD28家族的重要负性共刺激信号途径，已证实能够通过抑制T细胞的活化增殖及细胞因子的产生来负调控免疫应答，参与免疫耐受及自身免疫性疾病、慢性感染、肿瘤等慢性疾病。本文综述了PD-1/PD-L1信号途径的生物学特点和功能及其在口腔扁平苔藓、慢性牙周炎、口腔恶性肿瘤等口腔慢性疾病中的研究，并探讨了调节该通路为口腔慢性疾病提供治疗的可能性。 [关键词]程序性细胞死亡-1/程序性细胞死亡配体-1；T细胞；治疗 [中图分类号]Q 257[文献标志码]A[doi]10.3969/j.issn.1673-5749.2012.01.019 Programmed death-1/programmed death-ligand 1 pathway and its regulation on oral chronic diseases Zhang Jing1, Zhou Gang1，2.[1. The State Key Laboratory Breeding Base of Basic Science of Stomatology（HubeiMOST） Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, China; 2. Dept. of Oral Medicine, Hospital of Stomatology, Wuhan University, Wuhan 430079, China] [Abstract]Programmed death-1（PD-1）/programmed death-ligand 1（PD-L1）, as the important member of B7-CD28 family, is a newly identified negative co-stimulatory pathway. It may play a critical immunoregulatory role, through inhibiting T cells activation and proliferation as well as cytokines production, in chronic diseases such as autoimmune diseases, chronic infections and tumors. Besides discussing the biological characteristics and functions of PD-1/PD-L1, this review mainly explores its regulation on oral chronic diseases including oral lichen planus, chronic periodontitis as well as oral malignant tumors and the therapeutic potential of PD-1/PD-L1 modulation in this filed. [Key words]programmed death-1/programmed death-ligand 1；T cell；treatment 程序性细胞死亡-1（programmed death-1，PD-1）/程序性细胞死亡配体-1（programmed death-ligand 1，PD-L1）作为B7-CD28家族的重要负性共刺激信号途径，已证实其通过抑制T细胞的活化增殖及细胞因子的产生来负调控免疫应答，参与免疫耐受及自身免疫性疾病、慢性感染、肿瘤等慢性疾病[1-2]。 本文就PD-1/PD-L1信号途径的生物学特点和作用以及PD-1/PD-L1信号途径在口腔慢性疾病中的研究进展作一综述。 1PD-1/PD-L1的生物学特点 PD-1最初是通过削减杂交技术在T细胞凋亡过程中发现的，最近研究认为，它是一种能够提供抑制信号的协同刺激分子[2]，为CD28家族成员之一，属于免疫球蛋白超家族Ⅰ型跨膜糖蛋白。PD-1主要表达于活化的T淋巴细胞、B淋巴细胞及巨噬细胞表面，在细胞表面以单体形式存在，由细胞外区、跨膜区和胞内区3个部分构成。胞外区是一个免疫球蛋白样的结构域，有4个重要N连接糖基化位点，能与其配体结合