bgem an in situ hybridization database of gene expression in the embryonic and adult mouse nervous systembgem原位杂交数据库的基因表达在胚胎和成年小鼠神经系统.pdfVIP

Community Page BGEM: An In Situ Hybridization Database of Gene Expression in the Embryonic and Adult Mouse Nervous System Susan Magdaleno☯¤a, Patricia Jensen☯¤b, Craig L. Brumwell, Anna Seal, Karen Lehman, Andrew Asbury, Tony Cheung, Tommie Cornelius, Diana M. Batten, Christopher Eden, Shannon M. Norland, Dennis S. Rice¤c, Nilesh Dosooye, Sundeep Shakya, Perdeep Mehta, Tom Curran* Introduction designed to document the expression gene expression viewer has proven to The challenge of the postgenomic patterns of all genes in the nervous be an ideal tool for comparing gene era is not only to assign functions to system and to generate transgenic family members, genes whose products individual genes, but also to determine mice expressing reporter constructs participate in ligand–receptor how sets of genes act in concert to that recapitulate the authentic interactions, and genes involved in control biological processes. This expression patterns of selected genes. signal transduction pathways. BGEM formidable task is even more daunting GENSAT is supported by the National can be browsed, or the database when one attempts to understand the Institutes of Neurological Disorders can be systematically searched using complex genetic programs underlying and Stroke and by the National a variety of gene identifi ers such Institutes of Health Neurosciences as the offi cial gene symbol, name, nervous system development. More than half of the approximately 25,000 Blueprint (http:⁄⁄neuroscienceblu alias, genetic location