diclofenac inhibits tumor growth in a murine model of pancreatic cancer by modulation of vegf levels and arginase activity双氯芬酸抑制胰腺癌的肿瘤的生长在小鼠模型中vegf水平和精氨酸酶活动的调制.pdfVIP

Diclofenac Inhibits Tumor Growth in a Murine Model of Pancreatic Cancer by Modulation of VEGF Levels and Arginase Activity Nina Mayorek*, Nili Naftali-Shani, Myriam Grunewald Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada (IMRIC), The Hebrew University-Hadassah Medical School, Jerusalem, Israel Abstract Background: Diclofenac is one of the oldest anti-inflammatory drugs in use. In addition to its inhibition of cyclooxygenases (COX), diclofenac potently inhibits phospholipase A (PLA ), thus yielding a broa