efficacy of a low-cost, inactivated whole-cell oral cholera vaccine results from 3 years of follow-up of a randomized, controlled trial功效的低成本、灭活全细胞口服霍乱疫苗3年的随访结果的随机对照试验.pdfVIP

Efficacy of a Low-Cost, Inactivated Whole-Cell Oral Cholera Vaccine: Results from 3 Years of Follow-Up of a Randomized, Controlled Trial 1 1 2 1 2 2 Dipika Sur , Suman Kanungo , Binod Sah , Byomkesh Manna , Mohammad Ali , Allison M. Paisley , 1 2 1 2 2 Swapan K. Niyogi , Jin Kyung Park , Banawarilal Sarkar , Mahesh K. Puri , Deok Ryun Kim , Jacqueline L. 2 3 2 4 5 2,6 Deen , Jan Holmgren , Rodney Carbis , Raman Rao , Nguyen Thu Van , Seung Hyun Han , Stephen 3 7 8 8 1 Attridge , Allan Donner , Nirmal K. Ganguly , Sujit K. Bhattacharya , G. Balakrish Nair , John D. Clemens2*, Anna Lena Lopez2 1 National Institute of Cholera and Enteric Diseases, Kolkata, India, 2 International Vaccine Institute, Seoul, Republic of Korea, 3 University of Gothenburg, Gothenburg, Sweden, 4 Shantha Biotechnics, Hyderabad, India, 5 Company for Vaccine and Biologicals, Hanoi, Vietnam, 6 Seoul National University, Seoul, Korea, 7 University of Western Ontario, London, Ontario, Canada, 8 Indian Council of Medical Research, New Delhi, India Abstract Background: Killed oral cholera vaccines (OCVs) have been licensed for use in developing countries, but protection conferred by licensed OCVs beyond two years of follow-up has not been demonstrated in randomized, clinical trials. Methods/Principal Findings: We conducted a clust