efficacy of artesunate + sulfamethoxypyrazinepyrimethamine versus praziquantel in the treatment of schistosoma haematobium in children青蒿琥酯的效果+ sulfamethoxypyrazinepyrimethamine埃及血吸虫与吡喹酮治疗.pdfVIP

Efficacy of Artesunate + Sulfamethoxypyrazine/ Pyrimethamine versus Praziquantel in the Treatment of Schistosoma haematobium in Children 1 1 ´ 1 1 ´ 1 Mahamadou S. Sissoko *, Abdoulaye Dabo , Hamidou Traore , Mouctar Diallo , Boubacar Traore , ´ 1 ´ 1 ´ 1 ´ 1 ´ 1 Drissa Konate , Boubacar Niare , Moussa Diakite , Bourama Kamate , Abdrahamane Traore , 1 1 ´ 1 2 2 Aboudramane Bathily , Amadou Tapily , Ousmane B. Toure , Sarah Cauwenbergh , Herwig F. Jansen , Ogobara K. Doumbo1 1 Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Odonto-Stomatology, Malaria Research and Training Center, University of Bamako, Bamako, Mali, 2 Dafra Pharma nv, Turnhout, Belgium Abstract Background: This study was conducted to determine the efficacy of the antimalarial artemisinin-based combination therapy (ACT) artesunate +sulfamethoxypyrazine/pyrimethamine (As+SMP), administered in doses used for malaria, to treat Schistosoma haematobium in school aged children. Methodology/Principal Findings: The study was conducted in Djalakorodji, a peri-urban area of Bamako, Mali, using a double blind setup in which As+SMP was compared with praziquantel (PZQ). Urine samples were examined for Schistosoma haematobium on days 21, 0, 28 and 29. Detection of haematuria, and haematological and biochemical exams were conducted on day 0 and day 28. Clinical exams were performed