elevated glutamatergic compounds in pregenual anterior cingulate in pediatric autism spectrum disorder demonstrated by 1h mrs and 1h mrsi高架glutamatergic化合物pregenual前扣带小儿自闭症谱系障碍证明了1 h和1 h mrsi夫人.pdfVIP

Elevated Glutamatergic Compounds in Pregenual Anterior Cingulate in Pediatric Autism Spectrum Disorder Demonstrated by 1H MRS and 1H MRSI 3 1 2 3 1 1 Anthony Bejjani , Joseph O’Neill *, John A. Kim , Andrew J. Frew , Victor W. Yee , Ronald Ly , 4 5 1,6 2,6 3,6 Christina Kitchen , Noriko Salamon , James T. McCracken , Arthur W. Toga , Jeffry R. Alger , Jennifer G. Levitt1 1 Division of Child and Adolescent Psychiatry, Semel Institute for Neurosciences, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America, 2 Laboratory of Neuroimaging, Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America, 3 Ahmanson-Lovelace Brain Mapping Center, Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America, 4 Department of Biostatistics, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America, 5 Department of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America, 6 Brain Research Institute, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America Abstract Recent research in autism spectrum disorder (ASD) has aroused interest in anterior cingulate cortex and in the neurometabolite glutamate. We report two studies of pregenual anterior cingulate cortex (pACC) in pediatric ASD. First, we acquired in vivo single-voxel proton magnetic resonance