elevated level of wnt5a protein in localized prostate cancer tissue is associated with better outcomewnt5a蛋白质的高水平局限性前列腺癌组织中更好的结果.pdfVIP

Elevated Level of Wnt5a Protein in Localized Prostate Cancer Tissue Is Associated with Better Outcome 1,2 4 ¨ 2,4 ¨ 4 5 Azharuddin Sajid Syed Khaja , Leszek Helczynski , Anders Edsjo , Roy Ehrnstrom , Anna Lindgren , 1 3. 1,2 . David Ulmert , Tommy Andersson , Anders Bjartell * ˚ ¨ 1 Division of Urological Cancers, Department of Clinical Sciences, Lund University, Skane University Hospital, Malmo, Sweden, 2 Center for Molecular Pathology, Lund ˚ ¨ ˚ University, Skane University Hospital, Malmo, Sweden, 3 Division of Cell and Experimental Pathology, Department of Laboratory Medicine, Lund University, Skane ¨ ˚ ¨ University Hospital, Malmo, Sweden, 4 University and Regional Laboratories Region Skane, Clinical Pathology, Malmo, Sweden, 5 Department of Mathematical Statistics, Center for Mathematical Sciences, Lund University, Lund, Sweden Abstract Background: Wnt5a is a non-canonical secreted glycoprotein of the Wnt family that plays an important role in cancer development and progression. Previous studies report that Wnt5a is upregulated in prostate cancer and suggested that Wnt5a affects migration and invasion of prostate tumor cell. This study aimed to evaluate