elevated serum levels of interferon-regulated chemokines are biomarkers for active human systemic lupus erythematosusinterferon-regulated趋化因子的升高血清生物标志物对人类系统性红斑狼疮活动.pdfVIP

PLoS MEDICINE Elevated Serum Levels of Interferon-Regulated Chemokines Are Biomarkers for Active Human Systemic Lupus Erythematosus 1 1 2 3 1 1 Jason W. Bauer , Emily C. Baechler , Michelle Petri , Franak M. Batliwalla , Dianna Crawford , Ward A. Ortmann , 1 3 4 3 1*¤ Karl J. Espe , Wentian Li , Dhavalkumar D. Patel , Peter K. Gregersen , Timothy W. Behrens 1 Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America, 2 Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, 3 North Shore Long Island Jewish Research Institute, Manhasset, New York, United States of America, 4 Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America Funding: See section at end of A B S T R A C T manuscript. Competing Interests: See section at end of manuscript. Background Academic Editor: Richard Systemic lupus erythematosus (SLE) is a serious systemic autoimmune disorder that affects Sontheimer, University of Iowa, multiple organ systems and is characterized by unpredictable flares of disease. Recent evidence United States of America indicates a role for type I interferon (IFN) in SLE pathogenesis; however, the downstream effects Citation: Bauer JW, Baechler EC, of IFN pathway activation are not well understood. Here we test the hypot