elevated proteasome capacity extends replicative lifespan in saccharomyces cerevisiae在酿酒酵母蛋白酶体容量扩展复制寿命升高.pdfVIP

Elevated Proteasome Capacity Extends Replicative Lifespan in Saccharomyces cerevisiae 1. 2,3. 1¤ ¨ 4 5,6 Undine Kruegel , Brett Robison , Thomas Dange , Gunther Kahlert , Joe R. Delaney , Soumya 2 3 3 5 5 Kotireddy , Mitsuhiro Tsuchiya , Scott Tsuchiyama , Christopher J. Murakami , Jennifer Schleit , George 5,6 5 1 4 5 2,3 Sutphin , Daniel Carr , Krisztina Tar , Gunnar Dittmar , Matt Kaeberlein *, Brian K. Kennedy *, Marion Schmidt1* 1 Department of Biochemistry, Albert Einstein College of Medicine, New York, New York, United States of America, 2 Department of Biochemistry, University of Washington, Seattle, Washington, United States of America, 3 Buck Institute, Novato, California, United States of America, 4 Max Delbrueck Center for Molecular Medicine, Berlin, Germany, 5 Department of Pathology, University of Washington, Seattle, Washington, United States of America, 6 Department of Molecular and Cellular Biology Program, University of Washington, Seattle, Washington, United States of America Abstract Aging is characterized by the accumulation of damaged cellular macromolecules caused by declining repair and elimination pathways. An integral component employed by cells to counter toxic protein aggregates is the conserved ubiquitin/ proteasome system (UPS). Previous studies have described an age-dependent decline of proteasomal function