simple analysis used in diagnosis and follow-up of schizophrenic patients简单分析用于精神分裂症病人的诊断和随访.pdfVIP

Hindawi Publishing Corporation Journal of Automated Methods and Management in Chemistry Volume 2006, Article ID 79038, Pages 1–5 DOI 10.1155/JAMMC/2006/79038 Simple Analysis Used in Diagnosis and Follow-up of Schizophrenic Patients Faten A. Nour El-Dien,1 Reham G. El-Nahas,2 and Ahmed G. El-Nahas3 1 Chemistry Department, Faculty of Science, Cairo University, Giza 1263, Egypt 2 Chemistry Administration, 12 Ramsis square, Cairo, Egypt 3 Abbasia Psychiatric Hospital, Salah Salem Street, Cairo, Egypt Received 31 July 2006; Accepted 6 September 2006 Dopamine acts as neurotransmitter in the central and peripheral sympathetic nervous system. Determination of dopamine (DO) was performed by spectrophotometric analysis depending on the formation of new colored compound. The proposed procedure was efficient in quantitative determination of DO as pure material in pharmaceutical preparations and in urine samples. DO concentration in urine sample of patient confirms the affection with schizophrenia and the proposed procedure was used to facilitate diagnosis and followup of schizophrenic patients. It is recommended to apply the proposed procedures as routine analysis in pharmaceutical companies for quality control and in analytical laboratories to diagnose and follow up schizophrenia. Copyright © 2006 Faten A. Nour El-Dien et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 1. INTRODUCTION catecholamine infusion [16]. Flow injection analysis (FIA) system using tubular electrode was used in the determination Dopamine a