the effect of bradykinin b2 receptor polymorphisms on the susceptibility and severity of osteoarthritis in a chinese cohort缓激肽b2受体多态性的影响在中国人群易感性和严重程度的骨关节炎.pdfVIP

Hindawi Publishing Corporation Journal of Biomedicine and Biotechnology Volume 2012, Article ID 597637, 5 pages doi:10.1155/2012/597637 Research Article The Effect of Bradykinin B2 Receptor Polymorphisms on the Susceptibility and Severity of Osteoarthritis in a Chinese Cohort Shuo Chen, Yong Zhou, Jun Li, Le-Qun Shan, and Qing-Yu Fan Department of Orthopedics Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an 710038, China Correspondence should be addressed to Qing-Yu Fan, drshuochen007@ Received 13 April 2012; Accepted 12 June 2012 Academic Editor: Thomas Liehr Copyright © 2012 Shuo Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. The B2-bradykinin receptor (BDKRB2) has been reported to associate with onset and development of Osteoarthritis (OA); however, the role of BDKRB2 genetic polymorphisms in OA remains unknown. Method. A total of 245 patients with primary knee OA and 264 healthy volunteer were recruited. BDKRB2 gene polymorphisms, −58T/C and +9/−9 bp polymorphisms, were genotyped. Results. The genotype distributions and allele frequencies of +9/−9 bp polymorphisms significantly differed between OA and control subjects. Logistic regression analysis showed carriers with −9/−9 genotype had a significantly increased risk for knee OA compared with the +9/+9 genotype (adjusted OR = 2.356, P 0.001). The OR for −9 allele carriage was significantly higher than +9 allele carriage (adjusted OR = 1.52, P 0.001). The +9/−9 bp polymorphisms also determined the OA radiographic severity. The presence of −9 bp was associated with severer OA. T