the effect of mycobacterium avium complex infections on routine mycobacterium bovis diagnostic tests鸟型结核菌感染的影响在日常牛结核分枝杆菌诊断测试.pdfVIP

SAGE-Hindawi Access to Research Veterinary Medicine International Volume 2011, Article ID 145092, 7 pages doi:10.4061/2011/145092 Research Article The Effect of Mycobacterium avium Complex Infections on Routine Mycobacterium bovis Diagnostic Tests Claire Barry,1 David Corbett,1 Douwe Bakker,2 Peter Andersen,3 Jim McNair,4 and Sam Strain4 1 Veterinary Sciences Division, Agri-Food and Biosciences Institute, Stoney Road, Stormont, Belfast BT4 3SD, Northern Ireland 2 Central Veterinary Institute, P.O. Box 65, Edelhertweg 15, 8200 AB Lelystad, The Netherlands 3 Department of Infectious Immunology, Statens Serum Institut, Artillerivej, 2300 Copenhagen, Denmark 4 Veterinary Sciences Division, Agri-food and Biosciences Institute, Stoney Road, Stormont, Belfast BT4 3SD, Northern Ireland Correspondence should be addressed to Sam Strain, samuel.strain@.uk Received 14 January 2011; Accepted 16 April 2011 Academic Editor: Michael D. Welsh Copyright © 2011 Claire Barry et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Bovine tuberculosis (bTB) is diagnosed in naturally infected populations exposed to a wide variety of other pathogens. This study describes the cell-mediated immune responses of cattle exposed to Mycobacterium avium subspecies paratuberculosis (Map) and Mycobacterium avium subspecies avium with particular reference to routine antefmortem Mycobacterium bovis diagnostic tests. The IFN-γ released in response to stimulated blood was found to peak later in the Map-exposed group and was more sustained when compared to the Maa-exposed group. There was a very close correlation betw