the effect of the removal of the area postrema on insulin and igf-1-induced cardiovascular and sympathetic nervous responses切除的影响区域postrema胰岛素和igf-1-induced心血管交感神经反应.pdfVIP

Int. Jnl. Experimental Diab. Res., Vol. 1, pp. 59-67 (C) 2000 OPA (Overseas Publishers Association) N.V. Reprints available directly from the publisher Published by license under Photocopying permitted by license only the Harwood Academic Publishers imprint, part of The Gordon and Breach Publishing Group. Printed in Malaysia. The Effect of the Removal of the Area Postrema on Insulin and IGF-l-Induced Cardiovascular and Sympathetic Nervous Responses RENEE FORD, HUIQING LU, ZHENGBO DUANMU, TADEUSZ SCISLO and JOSEPH C. DUNBAR* Department of Physiology, Wayne State University School of Medicine, 540 E. Canfield, Detroit, M148201, USA (Received 19 May 1999; Revised 8 September 1999; In final form 28 September 1999) Previous studies have demonstrated that insulin and and that the greater depressor response to IGF-1 is IGF-1 both increase lumbar sympathetic nerve ac- likely due to enhanced vascular sensitivity in APX tivity (LSNA) and decrease mean arterial pressure rats. The increased HR and LSNA following insulin (MAP). We hypothesized that the peripheral re- were likely mediated by an increased reflexive sponses to insulin and IGF-1 are mediated, at least response to hypoglycemia. in part, via the central nervous system. In this study we determined the effects of the peripheral admin- istration of both insulin and IGF-1 on cardiovascular Keywords: Area postrema, insulin, IGF-1, sympathetic ner- dynamics and LSNA following removal of the area vous activity, blood pressure postrema (APX), a major site