the effect of topical local anesthetics on thermal pain sensitivity in patients with irritable bowel syndrome当地局部麻醉剂的影响在热疼痛敏感性肠易激综合症患者.pdfVIP

Hindawi Publishing Corporation Pain Research and Treatment Volume 2012, Article ID 438674, 9 pages doi:10.1155/2012/438674 Research Article The Effect of Topical Local Anesthetics on Thermal Pain Sensitivity in Patients with Irritable Bowel Syndrome Anthony Rodrigues,1 Christopher D. King,2 Fong Wong,3 Joseph L. Riley III,2 Siegfried Schmidt,4 and Andre P. Mauderli3 1 Department of Child Neurology, Floating Hospital for Children at Tufts Medical Center and Tufts University School of Medicine, Boston, MA 021111, USA 2 Department of Behavioral Sciences, College of Dentistry, University of Florida, Gainesville, FL 32610, USA 3 Department of Restorative Dental Sciences, College of Dentistry, University of Florida, Gainesville, FL 32610, USA 4 Community Health and Family Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA Correspondence should be addressed to Fong Wong, fwong@dental.ufl.edu Received 21 October 2011; Revised 19 December 2011; Accepted 19 December 2011 Academic Editor: Donald A. Simone Copyright © 2012 Anthony Rodrigues et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Generalized hypersensitivity that extends into somatic areas is common in patients with irritable bowel syndrome (IBS). The sensitized state, particularly assessed by experimental methods, is known to persist even during remissions of clinical pain. It was hypothesized that disease-related nociceptive activity in the gut maintains a systemic-sensitized state. The present study evaluated responses to prolonged thermal stimuli maintained at constant temperature or constant pain intensity