the effect of nanoparticle size on cellular binding probability纳米颗粒大小的影响细胞结合概率.pdfVIP

Hindawi Publishing Corporation Journal of Atomic, Molecular, and Optical Physics Volume 2012, Article ID 404536, 7 pages doi:10.1155/2012/404536 Research Article The Effect of Nanoparticle Size on Cellular Binding Probability Vital Peretz,1 Menachem Motiei,2 Chaim N. Sukenik,1 and Rachela Popovtzer2 1 The Department of Chemistry, The Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat Gan 52900, Israel 2 Faculty of Engineering, The Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat Gan 52900, Israel Correspondence should be addressed to Rachela Popovtzer, rachela.popovtzer@biu.ac.il Received 12 March 2012; Accepted 9 April 2012 Academic Editor: Zeev Zalevsky Copyright © 2012 Vital Peretz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Nanoparticle-based contrast agents are expected to play a major role in the future of molecular imaging due to their many advantages over the conventional contrast agents. These advantages include prolonged blood circulation time, controlled biological clearance pathways, and specific molecular targeting capabilities. Recent studies have provided strong evidence that molecularly targeted nanoparticles can home selectively onto tumors and thereby increase the local accumulation of nanoparticles in tumor sites. However, there are almost no reports regarding the number of nanoparticles that bind per cell, which is a key factor that determines the diagnostic efficiency and sensitivity of the overall molecular imaging techniques. Hence, in this research we have quantitatively investigated the effect of th