the ppar-platelet connection modulators of inflammation and potential cardiovascular effectsppar-platelet连接炎症和潜在的心血管效应的调节器.pdfVIP

Hindawi Publishing Corporation PPAR Research Volume 2008, Article ID 328172, 16 pages doi:10.1155/2008/328172 Review Article The PPAR-Platelet Connection: Modulators of Inflammation and Potential Cardiovascular Effects S. L. Spinelli,1 J. J. O’Brien,2 S. Bancos,2 G. M. Lehmann,2 D. L. Springer,3 N. Blumberg,1 C. W. Francis,4 M. B. Taubman,5 and R. P. Phipps2 1 Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 608, Rochester, NY 14642, USA 2 Department of Environmental Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA 3 Cell Biology and Biochemistry, K4-12, Biological Sciences Division Battelle, Pacific Northwest Division, 902 Battelle Blvd, Richland, WA 99352, USA 4 MD-Hematology/Oncology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA 5 Department of Medicine, MD-Cardiology Unit, University of Rochester Medical Center, 601 Elmwood Avenue, Box 679-ccmc, Rochester, NY 14642, USA Correspondence should be addressed to R. P. Phipps, richard phipps@ Received 14 August 2007; Accepted 6 November 2007 Recommended by Brian N. Finck Historically, platelets were viewed as simple anucleate cells responsible for initiating thrombosis and maintaining hemostasis, but clearly they are also key mediators of inflammation and immune cell activation. An emerging body of evidence links platelet func- tion and thrombosis to vascular inflammation. Peroxisome proliferator-activated receptors (PPARs) play a major role in mod- ulating inflammation and, interestingly, PPARs (PPARβ/δ and PPARγ) were recently identified in platelets. Additionally, PPAR agonists attenuate platelet activation; an important d