the prokinetic face of ghrelin胃促生长素的prokinetic的脸.pdfVIP

Hindawi Publishing Corporation International Journal of Peptides Volume 2010, Article ID 493614, 11 pages doi:10.1155/2010/493614 Review Article The Prokinetic Face of Ghrelin Hanaa S. Sallam and Jiande D. Z. Chen Department of Internal Medicine, Division of Gastroenterolog, University of Texas Medical Branch, Galveston, TX 77550, USA Correspondence should be addressed to Jiande D. Z. Chen, jianchen@ Received 1 October 2009; Accepted 3 December 2009 Academic Editor: Serguei Fetissov Copyright © 2010 H. S. Sallam and J. D. Z. Chen. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This review evaluated published data regarding the effects of ghrelin on GI motility using the PubMed database for English articles from 1999 to September 2009. Our strategy was to combine all available information from previous literature, in order to provide a complete structured review on the prokinetic properties of exogenous ghrelin and its potential use for treatment of various GI dysmotility ailments. We classified the literature into two major groups, depending on whether studies were done in health or in disease. We sub-classified the studies into stomach, small intestinal and colon studies, and broke them down further into studies done in vitro, in vivo (animals) and in humans. Further more, the reviewed studies were presented in a chronological order to guide the readers across the scientific advances in the field. The review shows evidences that ghrelin and its (receptor) agonists possess a strong prokinetic potential to serve in the treatment of diabetic, neurogenic or idiopathic gastroparesis and