白眉蛇毒血凝酶联用酚妥拉明治疗肺结核咯血40例临床分析.PDFVIP

Vol.23 No.21 November 2012 HAINANMEDICALJOURNAL doi:10.3969/j.issn.1003-6350.2012.21.020 ·临床经验· 白眉蛇毒血凝酶联用酚妥拉明治疗肺结核咯血40例临床分析 粟仲锐，沈志芳，褚宏勋 （张家界市人民医院感染科，湖南 张家界 427000 ） 【摘要】 目的 观察白眉蛇毒血凝酶联用酚妥拉明治疗肺结核咯血的临床效果。方法 将76 例肺结核咯 血患者随机分为治疗组40 例和对照组36 例，治疗组采用白眉蛇毒血凝酶静脉注射联用酚妥拉明静滴，对照组采 用脑垂体后叶素持续静脉泵入。观察两组患者72 h 内疗效和不良反应。结果 治疗组显效率为85.0% ，总有效 率为95.0% ；对照组显效率为72.22% ，总有效率为74.99% 。两组显效率比较，差异无统计学意义(P ＞0.05) ；但总 有效率比较差异有统计学意义（P0.05 ）。治疗组不良反应发生率为7.5% ，对照组为77.8% ，差异具有统计学意义 （P0.05 ）。结论 白眉蛇毒血凝酶联用酚妥拉明治疗肺结核咯血临床疗效明显，副作用少，是治疗肺结核咯血 的较为理想有效药物。 【关键词】 咯血；白眉蛇毒血凝酶；酚妥拉明；脑垂体后叶素 【中图分类号】 R521 【文献标识码】A 【文章编号】 1003—6350（2012 ）21—049—03 Clinicalanalysisonhemocoagulasecombinedwithphentolamineinthetreatmentof40casesofhemoptysisin tuberculosis.SU Zhong-rui, SHEN Zhi-fang, CHU Hong-xun. Department of Infection, Peoples Hospital of Zhangjiajie City, Zhangjiajie 427000, Hunan, CHINA 【Abstract】 Objective To study the clinical effect of hemocoagulase combined with phentolamine in the treatment of patients with hemoptysis in tuberculosis. Methods Seventy-six patients with hemoptysis in tuberculosis were randomly divided into the study group and the control group. Patients in the study group (n=40) were treated with intravenous injection of hemocoagulase combined with intravenous drip of phentolamine as maintenance dose. Patients in the control group (n=36) were treated with pumping pituitary continuously. The effect and adverse reac- tions was observed during 72 hours. Results The total effective rate was 95.0% in the study group and 74.99% in the control group, showing statistically significant difference between the two groups (P0.05). The excellent and good rate was 85.0% in the study group