盐酸法舒地尔说明书（Fasudil hydrochloride instructions）.docVIP

盐酸法舒地尔说明书（Fasudil hydrochloride instructions） Category: Chemicals Category: 3.1 [name of drug] Generic name: Fasudil Hydrochloride Injection Name used before： Trade name: English Name: Fasudil Hydrochloride Injection Chinese Pinyin: Yansuan, Fashudier, Zhusheye Dosage form: injection [ingredients] Chemical name: Six hydrogen - 1 - - (5 - sulfonyl isoquinoline) - 1 (H) - 1, 4 - two hydrochloride. Chemical formula: Molecular formula: C14H17N3O2S? HCl Molecular weight: 327.83 [character] this product is white, white or yellowish crystalline powder. Odorless, slightly bitter taste. Wettability. This product is easily soluble in water, dissolved in methanol, slightly soluble in ethanol, soluble in chloroform, almost insoluble in ether. [pharmacological toxicology] of fasudil hydrochloride is a protein kinase inhibitor that intracellular calcium antagonist. The contraction of the vascular smooth muscle is due to the marked increase in Ca2+ concentration in the smooth muscle cells and the activation of key enzymes. When CA2+ reaches a certain concentration, it combines with CA2+ binding protein calmodulin to activate myosin light chain phosphorylase, and phosphorylation of myosin light chain leads to muscle contraction. During subarachnoid hemorrhage, various vasoconstrictor substances released by blood vessels participate in vasospasm, and finally, vasoconstriction is induced by the phosphorylation of myosin light chains. Fasudil hydrochloride by blocking the final stage of vascular contraction process, myosin light chain phosphorylation, to dilate blood vessels, inhibit vascular spasm. Acute toxicity: the oral administration of LD50 in mice and rats was 273.9 mg / kg in male, 277.3 mg / kg in female, 335 mg / kg in male, and 348 mg / kg in female. LD50 was 69.5mg / kg intravenously in mice. Subacute toxicity: Rats and monkeys were given intravenously for 1 months, and the dose of rats was 12.5mg / kg, monkey 3.125mg / kg. Chronic toxicity: Rats and monkeys were given int