高效液相法测定斯诺普利原料的含量（Determination of the content of raw materials in perindopril by high performance liquid chromatography）.docVIP

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高效液相法测定斯诺普利原料的含量（Determination of the content of raw materials in perindopril by high performance liquid chromatography）.doc

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高效液相法测定斯诺普利原料的含量（Determination of the content of raw materials in perindopril by high performance liquid chromatography）

高效液相法测定斯诺普利原料的含量（Determination of the content of raw materials in perindopril by high performance liquid chromatography） Determination of the content of raw materials in perindopril by high performance liquid chromatography Update Date: 2011-09-26 Yang is managing Liu Xijun A HPLC method was established for the determination of the chromatographic conditions of c.. Taking Shimpack CLC-ODS as stationary phase, methanol: 0.1% phosphoric acid solution (35: 65 V: V) as the mobile phase, the flow rate of 1 ml / min, the column temperature of 40 DEG C, the UV detection wavelength was 220nm, the internal standard of phenobarbital, internal standard method, in the concentration range of the detected within (3.384 ~ 1692 g / ml), the linear relationship between the peak height ratio and the concentration of the sample is good (r = 0.9999). The difference between the daily peak and the drug peak was 6.39%, and the difference between the impurity peak and the drug peak was good, and the reproducibility of the method was better than 5.41%. The result shows that this method is simple, sensitive and rapid in analysis. It can be used as a method for the determination of the content of perindopril. Keywords HPLC Determination, of, S-nitrosocaptopril, by, HPLC Yang, Zhengguan, Liu, Xijun (Department, of, Clinical, Pharmacology, Fuzhou, General, Hospital, of, Nanjing, Military, Fuzhou) Abstract The HPLC method was founded to determination of S-nitrosocaptopril.The chromatographic condition:stationary phase was Shimpack CLC-ODS, mobile phase was a mixture of methanol:0.1%phosphate acid in a ratio of 3: 65 (V / V) at flow rate of detector was set 1 Ml.min1, at 220 nm, internal standard was barbiphenyl.There is linear relationship between concentration of 3.384 g ml / and 1692 g / ml.The precision of method were (inter-day) 5.4% 6.39% and (intra-day).The raw material and impure material of S-nitrosocaptopril was well separated.The results show that the method is simple, fast and accur