nalmefene hydrochloride for neurosurgical anesthesia recovery vascular interventional clinical observation（盐酸nalmefene神经外科麻醉恢复血管介入临床观察）.docVIP

Nalmefene hydrochloride for neurosurgical anesthesia recovery vascular interventional clinical observation Abstract: Objective nalmefene hydrochloride in the treatment of vascular interventional neurosurgical anesthesia resuscitation clinical efficacy and safety. Methods endovascular neurosurgery hospital treatment of patients, 50 cases were randomly divided into treatment group and control group of 25 cases, Two groups of patients were using total intravenous general anesthesia after surgery 2min given experimental drugs when patients wake rated up to 5 timeshare Steward extubation, patients were given the test drug to record extubation time used the treatment group extubation time was significantly shorter than the control group. Both groups were no significant adverse reactions. Conclusions nalmefene hydrochloride vascular interventional procedures for neurosurgical anesthesia recovery safe and effective, can significantly shorten the time to extubation. Keywords: nalmefene, endovascular therapy, extubation time Neurosurgery increasing vascular interventional surgery, special surgical approach and the environment, requiring anesthesia in patients after regaining consciousness, coupled with prescriptive actions do increase after transit security. Nalmefene hydrochloride injection as a novel opioid receptor antagonists [1], which can effectively antagonize opioid overdose induced respiratory depression and other adverse reactions [2], intravenous nalmefene can generate receptor antagonism 2min, 5min will reach peak plasma concentration [ 3] [4] In order to understand nalmefene hydrochloride vascular interventional therapy in neurosurgery anesthesia recovery in the clinical efficacy and safety, the following clinical observation. 1 Materials and Methods 1.1 Case Selection Neurosurgery in our hospital 50 cases of vascular interventional treatment of patients, aged 18 to 65 years, BMI 20-30, ASA grade Ⅰ - Ⅱ grade, unconscious barriers, no liver fun