adefovir dipivoxil for the treatment of chronic hepatitis b clinical observation（阿德福伟治疗慢性乙型肝炎的临床观察）.docVIP

Adefovir dipivoxil for the treatment of chronic hepatitis B clinical observation Abstract: Objective: To investigate adefovir dipivoxil clinical efficacy and adverse effects of treatment of chronic hepatitis B. Methods: Select from June 2010 to June 2011 chronic hepatitis B patients admitted to our hospital, 98 cases, were randomly divided 49 cases for each of the observation group and the control group, the control group of patients given bicyclol 100 mg / d, ursodeoxycholic acid 250 mg / d, one day, once every six months, to observe patients in the control group treatment given on the basis of adefovir dipivoxil 10 mg / d, twice a day, once every 6 months after the end of treatment, the clinical efficacy of the two groups were compared, the observed improvement in liver function indicators and adverse drug reaction. Results: The treatment after the end of the observation group, the total effective rate was 90.77%, significantly higher than 72.31%, the difference was statistically significant (χ 2 = 5.796, P lt;0.05. observation group, alanine aminotransferase (ALT, aspartate aminotransferase (AST, serum albumin (ALB, serum total bilirubin (TBiL recovery conditions are better than the control group, the differences were statistically significant (P lt;0.05, after the end of treatment, the two groups were not liver deterioration of renal function and other adverse reactions, adverse reactions differences not statistically significant (Pgt; 0.05. Conclusion: Adefovir dipivoxil treatment of chronic hepatitis B patients with significant liver function recovery, no significant adverse reactions occurred worthy of clinical promote the use of. Keywords: chronic hepatitis B, adefovir dipivoxil, clinical efficacy Hepatitis B is one of the major diseases threatening the global human health has been reported that the 5-year survival rate of only 14% [1] this article the author used the co-administration of adefovir dipivoxil treatment of chronic hepatitis B, and achi