a multi-center, qualitative assessment of pediatrician and maternal perspectives on rotavirus vaccines and the detection of porcine circovirus一个多中心,儿科医生和产妇的定性评估的角度对轮状病毒疫苗和猪圆环病毒的检测.pdfVIP

Payne et al. BMC Pediatrics 2011, 11:83 /1471-2431/11/83 RESEARCH ARTICLE Open Access A Multi-Center, Qualitative Assessment of Pediatrician and Maternal Perspectives on Rotavirus Vaccines and the Detection of Porcine circovirus 1* 2,3 4 5 1 6 Daniel C Payne , Sharon Humiston , Douglas Opel , Allison Kennedy , Mary Wikswo , Kimberly Downing , 4 4 7 2 8 7 Eileen J Klein , Ana Kobayashi , David Locke , Christina Albertin , Claudia Chesley and Mary A Staat Abstract Background: In 2010, researchers using novel laboratory techniques found that US-licensed rotavirus vaccines contain DNA or DNA fragments from Porcine circovirus (PCV), a virus common among pigs but not believed to cause illness in humans. We sought to understand pediatricians’ and mothers’ perspectives on this finding. Methods: We conducted three iterations of focus groups for pediatricians and non-vaccine hesitant mothers in Seattle, WA, Cincinnati, OH, and Rochester, NY. Focus groups explored perceptions of rotavirus disease, rotavirus vaccination, and attitudes about the detection of PCV material in rotavirus vaccines. Results: Pediatricians understood firsthand the success of rotavirus vaccines in preventing severe acute gastroenteritis among infants and young children. They measured this benefit against the theoretical risk of DNA material from PCV in rotavirus vaccines, determining overall that the PCV finding was of no clinical significance. Particularly influential was the realization that the large, randomized clinical trials that found both vaccines to be highly effective and safe were co