a planar conformation and the hydroxyl groups in the b and c rings play a pivotal role in the antioxidant capacity of quercetin and quercetin derivatives平面构象和b和c的羟基环发挥关键作用,槲皮素和槲皮素衍生物的抗氧化能力.pdfVIP

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a planar conformation and the hydroxyl groups in the b and c rings play a pivotal role in the antioxidant capacity of quercetin and quercetin derivatives平面构象和b和c的羟基环发挥关键作用,槲皮素和槲皮素衍生物的抗氧化能力.pdf

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a planar conformation and the hydroxyl groups in the b and c rings play a pivotal role in the antioxidant capacity of quercetin and quercetin derivatives平面构象和b和c的羟基环发挥关键作用,槲皮素和槲皮素衍生物的抗氧化能力

Molecules 2011, 16, 9636-9650; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Communication A Planar Conformation and the Hydroxyl Groups in the B and C Rings Play a Pivotal Role in the Antioxidant Capacity of Quercetin and Quercetin Derivatives Mohamed Moalin 1,2*, Gino P. F. van Strijdonck 2, Maud Beckers 2, Geja J. Hagemen 1, 2 1 1 Paul J. Borm , Aalt Bast and Guido R. M. M. Haenen 1 Department of Toxicology, Maastricht University, 6200 MD Maastricht, The Netherlands 2 Zuydlab, Hogeschool Zuyd, 6400 AN Heerlen, The Netherlands * Author to whom correspondence should be addressed; E-Mail: m.moalin@maastrichtuniversity.nl; Tel.: +31-43-388-1343; Fax: +31-43-388-4149. Received: 29 September 2011; in revised form: 11 November 2011 / Accepted: 14 November 2011 / Published: 21 November 2011 Abstract: The polyphenol quercetin (Q) that has a high antioxidant capacity is a lead compound in the design of antioxidants. We investigated the possibility of modifying quercetin while retaining its antioxidant capacity as much as possible. To this end, the antioxidant capacities of Q, rutin, monohydroxyethyl rutinoside (monoHER) and a series of synthesized methylated Q derivatives were determined. The results confirm that the electron donating effect of the hydroxyl groups is essential. It was also found that the re