a prospective study of twinning and perinatal mortality in urban guinea-bissau一个前瞻性研究在城市几内亚比绍的孪生和围产期死亡率.pdfVIP

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a prospective study of twinning and perinatal mortality in urban guinea-bissau一个前瞻性研究在城市几内亚比绍的孪生和围产期死亡率.pdf

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a prospective study of twinning and perinatal mortality in urban guinea-bissau一个前瞻性研究在城市几内亚比绍的孪生和围产期死亡率

Bjerregaard-Andersen et al. BMC Pregnancy and Childbirth 2012, 12:140 /1471-2393/12/140 RESEARCH ARTICLE Open Access A prospective study of twinning and perinatal mortality in urban Guinea-Bissau Morten Bjerregaard-Andersen1,2*, Najaaraq Lund1,3, Frida Staarup Jepsen1,3, Luis Camala1,4, 1,4 5,6,7 5,7 8 1,3 Margarida Alfredo Gomes , Kaare Christensen , Lene Christiansen , Dorte Møller Jensen , Peter Aaby , Henning Beck-Nielsen8, Christine Stabell Benn1,3 and Morten Sodemann1,2 Abstract Background: Despite twinning being common in Africa, few prospective twin studies have been conducted. We studied twinning rate, perinatal mortality and the clinical characteristics of newborn twins in urban Guinea-Bissau. Methods: The study was conducted at the Bandim Health Project (BHP), a health and demographic surveillance site in Bissau, the capital of Guinea-Bissau. The cohort included all newborn twins delivered at the National Hospital Simão Mendes and in the BHP study area during the period September 2009 to August 2011 as well as singleton controls from the BHP study area. Data regarding obstetric history and pregnancy were collected at the hospital. Live children were examined clinically. For a subset of twin pairs zygosity was established by using genetic markers. Results: Out of the 5262 births from mothers included in the BHP study area, 94 were twin births, i.e. a community twinning rate of 18/1000. The monozygotic rate was 3.4/1000. Perinatal mortality among twins vs. singletons was 218/1000 vs. 80/1000 (RR = 2.71, 95% CI: 1.93-3.80). Among the 13783 hospital births 388 were twin births (28/1000). The hospital perinatal twin mortality was 237/1000. Birth weight 2000g