high hyperhomocysteinemia on endothelial function and serum soluble vascular cell adhesion molecule（高半胱氨酸在内皮功能和血清可溶性血管细胞粘附分子）.docVIP

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high hyperhomocysteinemia on endothelial function and serum soluble vascular cell adhesion molecule（高半胱氨酸在内皮功能和血清可溶性血管细胞粘附分子）.doc

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high hyperhomocysteinemia on endothelial function and serum soluble vascular cell adhesion molecule（高半胱氨酸在内皮功能和血清可溶性血管细胞粘附分子）

High hyperhomocysteinemia on endothelial function and serum soluble vascular cell adhesion molecule Papers to write network: Author: Ge Yuxia, segment cloud Friends, Ruan Li Tao, CAO Tie-sheng, Yuan Lijun, Lvfa Qin, Liu Jubilee [Keywords] peroxidase [Abstract] AIM: To investigate the effects of hyperhomocysteinemia HHCY on the function of endothelium by observing the changes of NO, ET and the activity of GSHPX and vascular cell adhesion molecule1 (VCAM1) in plasma of HHCY rabbits. METHODS: Eighteen New Zealand rabbits were randomized into methionine group (group B, n = 9and control group (group A, n = 9). Methionine group was fed with methioninerich diet of Lmethioine (0.8 g / kg per day) and normal control group was fed with normal diet. The levels of NO, GSHPX in plasma and the serum concentration of VCAM1 were measured at 20, 40, 60 and 80 d, and endothelium dependent dilation (EDD) and endothelium independent dilation (EID) were examined by high resolution ultrasound. RESULTS: In chronic hyperhomocysteinemia, the EDD of external iliac artery in methioine group was reduced significantly than that in control: 0 d, (15.3 + -2.6)%, 20 d, (5.1 + -1.7)%; 40 d, (2.7 + -1.0 )%, 60 d, (-4.1 + -1.3)% and 80 d, (-5.5 + -1.3)% (P lt;0.01). The EID in group B was reduced significantly compared with that in group A. The values #8203;#8203;of plasma in methioine group were markedly higher than those in the control group (P lt;0.05) while the levels of NO were lower than those in the control. In methioine group, the serum concentration of VCAM1 was also significantly higher than that in the control group : 0 d, (0.066 + -0.003) μg / L, 20 d, (0.074 + -0.004) μg / L, 40 d, (0.078 + -0.008) μg / L, 60 d, (0.087 + -0.008) μg / L and 80 d, (0.098 + -0.010) μg / L (P lt;0.01). CONCLUSION: Chronic hyperhomocysteinemia leads to endothelia dysfunction in rabbits. EDD is reduced through the inactivation of NO by homocysteinemia and the serum concentration of VCAM1 is elevated i