high-dose mtx for pediatric leukemia chemotherapy-induced oral mucosal damage prevention and care（大剂量mtx对小儿白血病化疗所致口腔黏膜损害预防和护理）.docVIP

High-dose MTX for pediatric leukemia chemotherapy-induced oral mucosal damage prevention and care [Keywords] MTX leukemia oral mucositis Chemical treatment is one of the main methods of cancer treatment, during treatment of patients prone to different degrees of mouth ulcers, so that patients suffer great pain, fear the resulting psychological stress of chemotherapy, so chemotherapy should take effective measures, to prevent, reduce its toxicity. 1 Prevention 1.1 Protection of isolation of sick children should stay laminar flow room, the room must be disinfected, prohibit access to accompany bed, to avoid unnecessary movement. Strict bed rest. Room temperature requires 22 ~ 26 ℃, humidity 55% ~ 60% of a day 2 to 4 times windows open for ventilation to ensure indoor air fresh. Keep warm and prevent colds. 1.2 Most of the psychological care of sick children and parents have different levels of anxiety, fear, the nurse should communicate with the sick children and their parents, targeted psychological care, sick children and parents to enhance mental capacity, actively cooperate with treatment. 1.3 measures of care during chemotherapy prescribed application of granulocyte colony-stimulating factor injected with normal saline mouthwash bottle, you can achieve a double effect. Check blood once every other day to find granulocyte recovery. Prescribed application Thailand can or vancomycin and other antibiotics, to observe the drug side effects. should pay full attention to detoxification after chemotherapy, according to the amount of time for detoxification, the occurrence of gastrointestinal mucositis, should be adequate amount of folate added, Although after a detoxification period However, the delay of some drugs on the discharge still a good antagonist, to mitigate the continuing damage to body tissue. MTX is a class of anti-folate metabolism of anti-tumor agent, on a variety of animal tumor inhibition. MTX on proliferating cells sensitive