hplc method for the determination of the content of the ferulic acid the yiqiwenyang capsule（高效液相色谱方法测定阿魏酸yiqiwenyang胶囊的内容）.docVIP

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2017-09-06 发布于浙江
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hplc method for the determination of the content of the ferulic acid the yiqiwenyang capsule（高效液相色谱方法测定阿魏酸yiqiwenyang胶囊的内容）.doc

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hplc method for the determination of the content of the ferulic acid the yiqiwenyang capsule（高效液相色谱方法测定阿魏酸yiqiwenyang胶囊的内容）

HPLC method for the determination of the content of the ferulic acid the Yiqiwenyang capsule Author: Chen Jun, Xiao-Bing Zhang, Li Guoqiang, Huang Shaobin Keywords: Yiqiwenyang capsules Abstract: Objective To establish a HPLC method for determination of the active ingredients in the capsule of the Yiqiwenyang ferulic acid. Methods C18 column, mobile phase: methanol water glacial acetic acid (volume than 25:75:0.35 of detection wavelength of 320 nm. ferulic acid in the range of 0.02 ~ 0.20 μg peak area showed a linear relationship between the average recovery of ferulic acid capsules was 98.8%, RSD = 0.97%. CONCLUSION The method is simple, stable, effective control of the The quality of the preparation. Keywords: Yiqiwenyang capsules, high-performance liquid chromatography, ferulic acid Abstract: Objective To establish a method for the determination of ferulic acid in Yiqiwenyang capsules. Method Samples were extracted with ethyl acetate, and separated on a C18 column (5μm, 250 mm × 4.6 mm) using methanol-wateracetic acid (25:75: 035) as mobile phase. The detection wavelength was set at 320 nm. Results The calibration curve of ferulic acid was linear in the range of 0.02 ~ 0.20 μg. The average recovery was 98.8% with RSD 0.97% (n = 5). Conclusions The method could be used for the quality control of Yiqiwenyang capsules. Keywords:: Yiqiwenyang capsules; HPLC; ferulic acid The Yiqiwenyang capsule by the astragalus, sulfur, Angelica, Chuanxiong Shisanwei medicinal herbs processing and extraction of preparations yang qi, efficacy Huoxuetongluo. Determination method is not established in the existing quality standards, is not conducive to the preparation quality control. By prescription analysis, we selected determination Fang Zhongchen medicine angelica, Chuanxiong active ingredients of ferulic acid as a quality control indicators. According to the literature, ferulic acid has a significant expansion of the coronary blood vessels, increase coron