hyperbaric oxygen for experimental analysis of learning and memory function in rats with diffuse axonal injury recovery（高压氧对实验分析大鼠学习和记忆功能的脑弥漫性轴索损伤恢复）.docVIP

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hyperbaric oxygen for experimental analysis of learning and memory function in rats with diffuse axonal injury recovery（高压氧对实验分析大鼠学习和记忆功能的脑弥漫性轴索损伤恢复）.doc

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hyperbaric oxygen for experimental analysis of learning and memory function in rats with diffuse axonal injury recovery（高压氧对实验分析大鼠学习和记忆功能的脑弥漫性轴索损伤恢复）

Hyperbaric oxygen for experimental analysis of learning and memory function in rats with diffuse axonal injury recovery Author: Ren Jie Chang Yiu Ming Li Jinyuan sound Liu [Key Words] hyperbaric oxygen Keywords: hyperbaric oxygen; diffuse axonal injury; memory; hippocampus; choline O-acetyltransferase; rats Abstract: The purpose of the study of hyperbaric oxygen (HBO treatment of diffuse axonal injury in rats affect learning and memory function. Marmarou described falling body combat unit produced diffuse axonal injury (DAI rat model, a group of rats in injury Y-maze training before another group without prior training, were observed hyperbaric oxygen therapy on the injured rat maze space to identify the function of memory and learning, and immunohistochemical methods to observe the changes in the hippocampus ChAT-positive fibers express results whether Y-maze training, the number of conditioned reflex injury in rats (con-ditioned reflex number, CN was significantly higher than the control group (blank rats (P lt;0.05; advance Y maze training in rats caused by DAI injury, HBO group compared with the control group (control no significant difference in the CN Views; HBO treatment not pre-training group rats CN frequency was significantly less than the control group (P lt;0.05); injury in rats after HBO treatment hippocampus ChAT positive fibers was significantly enhanced Conclusion diffuse brain damage decreased learning ability and memory of rats, and hyperbaric oxygen therapy to improve brain injury in rats learning disabilities, but has little effect on the memory impairment; hyperbaric oxygen therapy can enhance neuronal activity in the hippocampus, ACh can inhibit post-traumatic degeneration of neurons, and this may be one of the mechanisms of hyperbaric oxygen to improve learning and memory impairment of brain injury in rats. Keywords: hyperbaric oxygen ation; diffuse axonl injury; memory; hippocampus; choline O-acetyltrans-ferase; rats Abstract