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conservation and divergence of gene families encoding components of innate immune response systems in zebrafish保护和散度的基因家族编码组件斑马鱼的先天免疫反应系统.pdf

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conservation and divergence of gene families encoding components of innate immune response systems in zebrafish保护和散度的基因家族编码组件斑马鱼的先天免疫反应系统

Volume 8, Issue 11, Article R251et al.Stein2007 Open Access Research Conservation and divergence of gene families encoding components of innate immune response systems in zebrafish * † † *† Cornelia Stein , Mario Caccamo , Gavin Laird and Maria Leptin Addresses: *Institute for Genetics, University of Cologne, Zuelpicher Str. 47, 50674 Cologne, Germany. †The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK. Correspondence: Maria Leptin. Email: mleptin@uni-koeln.de Published: 27 November 2007 Received: 20 April 2007 Revised: 30 October 2007 Genome Biology 2007, 8:R251 (doi:10.1186/gb-2007-8-11-r251) Accepted: 27 November 2007 The electronic version of this article is the complete one and can be found online at /2007/8/11/R251 © 2007 Stein et al.; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the articles original URL. gene families of fiImmune system proteins in zebrafishpAnalysis of several fish genomes reveals components of the insh and mammals./p nate immune system and identifies orthologous relationships between Abstract Background: The zebrafish has become a widely used model to study disease resistance and immunity. Although the genes encoding many components of immune signaling pathways have been found in teleost fish, it is not clear whether all components are present or whether the comp