still病（still病）.docVIP

still病（still病） adult still disease Adult Still disease is a disease of unknown etiology with long-term intermittent fever, a pleomorphic rash, arthritis or joint pain and sore throat are the main clinical manifestations, and accompanied by peripheral blood WBC and granulocyte hypertension and impaired liver function and other systems involved in the clinical syndrome, Wissler (1943) first after the report, Fanconi (1946) have been described, because of its clinical allergy like sepsis or infection cause, it is called allergic Subsepsis since 1995 500 cases have been reported in the literature, not reported more cases, so it is a more common disease. The two names have long been used internationally and domestically, and are collectively known as adult Still disease or, more specifically, AOSD Still onset (Adult, Stills, disease). There is a suggestion that this syndrome is a allergic disease between rheumatic fever and juvenile rheumatoid arthritis, which is very similar to acute systemic rheumatoid arthritis (Still disease) in juvenile rheumatoid arthritis. There is also a clinical stage or a clinical variant that may be considered a class of wind related events. But after a long-term observation, most patients do not leave joint ankylosis, deformity and other sequelae. Etiology and pathogenesis Not yet certain. According to the training of hemolytic streptococcus in many patients with alveolar, some patients and the incidence of vaccination, pollen, dust or food allergies, many joints and serosal tissue clinically, showed acute inflammation and immune process, with abnormal systemic involvement, and antibiotics ineffective corticotropin effectively, so that is a kind of infectious allergic reaction. Infection plays a role in the acute phase, while allergy acts throughout the course of the disease. Pathology Skin biopsy revealed dermal collagen edema and infiltration of neutrophils, lymphocytes, and plasma cells around capillaries. Articular synovial hypertrophy, e