18F-FDG PET-CT SUV在鼻咽癌T分期中价值.docVIP

18F-FDG PET/CT SUV在鼻咽癌T分期中价值 　 作者：孙新儒 胡莹莹 张旭 林晓平 梁培炎 樊卫， 陈明远 赵充 【摘要】 【目的】 探讨鼻咽癌病灶18F-FDG SUV在鼻咽癌T分期中的价值，以期能进一步指导临床工作。【方法】 收集113例鼻咽癌初诊患者首次放疗前的PET/CT资料，按照T分期分为4组：T1期6例，T2期18例，T3期64例，T4期25例。采用18F-FDG高摄取(SUV≥2.5)为阈值人工勾画感兴趣区(ROI)，在XELERIS 工作站上自动计算所勾画病灶的大小、SUVmax和SUVmean。分析SUV与T分期的关系。 【结果】 Kruskal-Wallis秩和检验显示，原发灶大小(Size)、SUVmax、SUVmean在T分期间差异有显著统计学意义(χ2 = 34.46， 17.02， 16.62; P均 lt; 0.01)。病灶大小和SUVmax、SUVmean之间的相关系数r分别为0.46和0.37，P lt; 0.01。鼻咽癌病灶的大小和SUVmax、SUVmean呈正相关。【结论】 18F-FDG PET/CT SUVmax、SUVmean在鼻咽癌T1 ～ T4分期中的差异有统计学意义，并随分期升高逐渐升高，具有一定的临床价值。 【关键词】 鼻咽癌; 体层摄影术，X线计算机; 氟脱氧葡萄糖F18; T分期 　Abstract： 【Objective】 The aim was to investigate the value of 18F-FDG standardized uptake value (SUV) in T stages of nasopharyngeal carcinoma (NPC)， and to guide clinical work further. 【Methods】 In total 113 histologically diagnosed NPC patients without any radiotherapy underwent 18F-FDG PET/CT in Cancer Center， Sun Yat-sen University between July 2005 and April 2008 were entered into this retrospective study. The patients were grouped according to T stage： T1， 6 patients; T2， 18 patients; T3， 64 patients; and T4， 25 patients. Using high 18F-FDG uptake (SUV≥2.5) to draw region of interest (ROI)， the maximum standardized uptake value (SUVmax)， and mean standardized uptake value (SUVmean) of ROI were calculated automatically in XELERIS workstation. The relationship between SUV and T stage was analyzed. 【Results】 Kruskal-Wallis rank sum test showed that the differences of primary tumor size， SUVmax， SUVmean， have a significant statistical significance (χ2 = 34.46， 17.02， 16.62; P lt; 0.01) in the T stages. The correlation coefficients between lesion size and SUVmax， SUVmean were 0.46 and 0.37， respectively (P lt; 0.01). The NPC lesion size and SUVmax， SUVmean were positive correlation. 【Conclusion】 18F-FDG SUVmax， SUVmean have a statistical difference in T1-T4 stages of NPC and gradually increased with the stages， which have some value in clinic. 　　鼻咽癌采取以放疗为主的治疗手段，精确的临床分期对于病人的合理治