NA方案及NP方案治疗晚期乳腺癌48例.docVIP

NA方案及NP方案治疗晚期乳腺癌48例 　 作者：郭亚焕, 南克俊，李春丽，张玮 【关键词】 乳腺肿瘤；长春瑞滨；表柔比星；顺铂 　　Chemotherapy of NA and NP regimens in 48 patients with advanced breast cancer 　　【Abstract】 AIM: To observe the effect and toxicity of NA and NP regimens for advanced breast cancer. METHODS: All cases of advanced breast cancer were treated with NA regimen（NVB+EADM, n=26）or NP regimen(NVB+DDP, n=22). The former refered to vinorelbine (NVB, 25 mg/m2 on day 1, 8) plus epirubicin (EADM, 60 mg/m2 on day 1) and the latter to vinorelbine (NVB, 25 mg/m2 on day 1, 8) plus cisplatin (DDP, 40 mg on day 1, 2, 3); both were performed every 3 to 4 weeks. RESULTS: NA regimen led to 61.5% response rate（RR）, median survival time of 25.8 months, and 1year survival rate of 61.5%. For 22 patients treated with NP regimen, the RR was 45.5%, the median survival time was 19.8 months, and the 1year survival rate was 68.2%. There was no statistically significant difference between the 2 groups in the RR of the initial treatment and the median survival time and the 1year survival rate (Pgt;0.05), However, The median time to progression(mTTP) in NA regimen was longer than that in NP regimen (8.5 vs 5.0 months, χ2＝4.2, P＝0.04). The main side effects were myelosuppression and gastrointestinal tract reaction, which were all reversible. CONCLUSION： NA regimen and NP regimen are effective and less toxic to patients with advanced breast cancer who suffered from relapse or distant metastasis. Both of the 2 regimens can be applied as the firstline chemotherapy for advanced breast cancer. 　　【Keywords】breast neoplasms; vinorelbine; epirubicin; cisplatin 　　【摘要】 目的： 评价NA、NP两种化疗方案治疗晚期乳腺癌的疗效及毒副反应. 方法： NA方案 (NVB+EADM)26例, NP方案 (NVB+DDP)22例. NA方案：长春瑞滨 （NVB） 25 mg/m2, d1, d8；表柔比星 （EADM） 60 mg/m2, d1. NP方案：长春瑞滨 (NVB) 25 mg/m2, d1, d8；顺铂 (DDP) 40 mg, d1, d2, d3. 上述两方案每3~4 wk为1个周期. 结果： NA方案有效率为 61.5%; 中位生存期25.8 mo; 1 a生存率61.5%. NP方案有效率为45.5%; 中位生存期19.8 mo;1 a生存率68.2%. NA方案与NP方案有效率、生存期及一年生存率比较，无统计学差异(Pgt;0.05). 中位疾病进展时间(mTTP)： NA组8.5 mo, NP组5.0 mo.