不同疗程神经节苷脂GM1治疗急性期脑梗死疗效观察.docVIP

不同疗程神经节苷脂GM1治疗急性期脑梗死疗效观察 　 作者：张倩，姚蔚，张立娟，张湘 【摘要】 目的 评价不同疗程神经节苷脂GM1（ 即单唾液酸神经节苷脂） 治疗 急性期脑梗死的疗效。 方法 选取急性期脑梗死病人60例，随机分为治疗Ⅰ组（短程组）、治疗Ⅱ组（长程组）和对照组各20例，3组常规治疗相同，治疗Ⅰ组加用神经节苷脂GM1 应用 7天，治疗Ⅱ组加用神经节苷脂GM1应用14天，2周后对患者进行神经功能缺损程度评分量表（NDS）和日常生活活动量表（ADL）的评分并比较。结果 治疗前3组NDS和ADL评分差异无显著性，治疗2周后治疗Ⅰ组与对照组比较差异有显著性（Plt;0.05），治疗Ⅱ组与对照组比较差异有非常显著性（Plt;0.01），治疗Ⅱ组与治疗Ⅰ组比较差异亦有显著性（Plt;0.05）。结论 脑梗死急性期应用长程神经节苷脂GM1治疗能更好地提高神经功能恢复，降低致残率，提高生活质量。 论文代写 【关键词】 脑梗死；急性期；神经节苷脂；神经节苷脂GM1 论文代写 【Abstract】 Objective To observe the clinical effect of ganglioside GM1 in different Treatment for acute cerebral infarction.Methods Sixty patients with acute cerebral infarction were randomly and equally assigned to the control group, the experiment group I （short period） and the experiment groupⅡ（long period）. The experiment group I was treated with ganglioside for 7 days, the experiment group II was treated with ganglioside for 14 days, the regular treatment was same for all participants. After two weeks, neurological deficit scale （NDS） and activity of daily living （ADL） were valued and compared. Results There were no significant differences of NDS and ADL among three groups before treatment. After two weeks of treatments, there were differences between the experiment group I and the control group（Plt;0.05）. The differences were significant between the experiment group II and the control group（Plt;0.01）. There were differences between the experiment group II and the experiment group I as well（Plt;0.05）. Conclusion The long period treatment with ganglioside GM1 for acute cerebral infarction could recover the neural function, decrease disability rate and improve the life quality. 论文代写 【Key words】 Cerebral infarction; Acute stage; Ganglioside GM1 毕业论文 脑梗死又称缺血性脑卒中，是指各种原因引起的脑部血液供应障碍，使局部脑组织发生不可逆损害，导致脑组织缺血、缺氧性坏死［1］。脑梗死后致残率高达80％，给患者家属及 社会 带来了很大的负担。我科采用不同疗程神经节苷脂GM1治疗急性期脑梗死，促进患者神经功能恢复，疗效满意，现报道如下。 　　1 资料与方法 1.1 病例选择及分组 选择我科2007年9月～2008年2月住院的60例脑梗死患者，均符合1995年全国第4届脑血管疾病学术会议修订的诊断标准，并经头颅CT或MRI确诊。将入选的60例患者随机分为对照组、治疗Ⅰ组、