人参须超微粉醇提液对去卵巢大鼠血脂影响.docVIP

人参须超微粉醇提液对去卵巢大鼠血脂影响 　作者：张益嘉，吴铁，吴怡，崔燎，张新乐，吴光樑， 周湘君，李彬 【摘要】 　　目的观察人参须超微粉醇提液对去卵巢大鼠血脂水平的调节作用。方法32 只 SD 雌性大鼠随机分为 4 组，每组 8 只，以去卵巢大鼠为血脂紊乱模型，预防用药90 d ，观察人参须超微粉醇提液中、低剂量等分别对大鼠血脂谱各值以及体重、肝脏、子宫重量等的影响。结果与假手术组比，去卵巢组大鼠体重、总胆固醇(TC)明显升高(P＜0.01或P＜0.05)，甘油三酯(TG)升高不明显，高密度脂蛋白胆固醇(HDL-c)和子宫重量显著下降(P＜0.01或P＜0.05)；与去卵巢组相比，人参须超微粉醇提液中、低剂量可显著降低 TC水平、升高 HDL-c 水平(P＜0.05或P＜0.01)，对体重、子宫重量没有显著影响，中剂量人参醇提液还能降低 TG(P＜0.05)与升高 HDL-c/TC 值(P＜0.01)。 结论去卵巢能造成大鼠血脂紊乱，中药人参须的超微粉醇提液能有效改善其血脂水平。 【关键词】 人参须 去卵巢大鼠 血脂类 　　Abstract：ObjectiveTo study the regulatory effects of the alcohol extracts of Ginseng fibrous root on the blood lipid of ovariectomized rats. Methods32 female Sprague-Dawley rats were randomly divided into sham operation group (sham)，ovariectomized group (OVX) and two different dosages of the alcohol extracts of ginseng fibrous root treated groups(GSLamp;GSM)． The levels of serum lipid and body weights，liver and uterus weight were measured after 90 days treatment.ResultsOvariectomized rats had much higher total cholesterol(TC) (P ＜0.05) and body weight (P ＜0.01) as compared to Sham group．A significant decrease in high density lipoprotein cholesterol(HDL-C) (P ＜0.01) and uterus weight(P ＜0.05) were also observed though no significant elevation in triglyeride (TG) was reported. GSL and GSM lowered serum TC(P ＜0.01) and enhanced HDL-C(P ＜0.05 or P ＜0.01)，and had no effect on body weight or uterus weight. GSM also enhanced HDL/TC value(P ＜0.01) and lowered TG(P ＜0.05) as well. ConclusionThe alcohol extracts of Ginseng fibrous root can regulate the blood lipid in ovarieetomized rats. 　　Key words：Ginseng fibrous root； Ovariectomy； Blood-lipid Spectrum 　　在当今人口老龄化的趋势下，诸如女性绝经后动脉粥样硬化、冠心病、骨质疏松症等多种老年性疾病的防治日益受人们关注。女性进入更年期后，由于卵巢内分泌功能衰退，雌激素水平下降而导致脂肪和胆固醇代谢失常［1］，使绝经女性血脂升高，使心血管疾病发病率和死亡率增加。亦有文献报道以去卵巢大鼠为血脂紊乱模型观察多种中药调节血脂的作用［2，3］。 　　人参须为名贵中药材、五加科植物人参的细支根及须根，亦有益气活血之功效。有研究发现，人参的主要有效成分人参皂苷对高胆固醇模型大鼠有一定降血脂作用 ［4］，但由于价格昂贵，从人参中提取皂苷成本较高。人参须价格一般仅为人参的1/l0～1/2，而其总皂苷的含量甚至可以高于人参中皂苷的含量［5］。为进一步开发中药人参，研究其调节血脂、抗动脉硬化机制，为其防治妇女绝经后血脂紊乱及动脉硬化提供药理学依据