吸烟、饮酒对胃部疾病幽门螺旋杆菌感染影响.docVIP

吸烟、饮酒对胃部疾病幽门螺旋杆菌感染影响 　【摘要】 目的 探讨吸烟、饮酒对胃部疾病Hp感染的影响。方法 对来院做胃镜检查的患者用随机采样方式，Hp采用快速尿素酶试验与组织学检测确诊幽门螺旋杆菌感染，通过问卷方式确定患者吸烟、饮酒的情况。结果 2186例患者中，630例吸烟者Hp的检出率为55.7%，1556例非吸烟者Hp的检出率为44.7%,两者差异有显著性(Plt;0.05)。322例饮酒患者Hp的检出率为54.3%,1864例非饮酒患者Hp的检出率为45.7%,两者差异无显著性(Pgt;0.05)。其中，284例烟酒嗜好者Hp的检出率为62.32%,1538例无烟酒嗜好者Hp的检出率为46.62%，两者差异有显著性(Plt;0.05)。结论 吸烟能增加幽门螺旋杆菌的感染率，并可能导致常见胃部疾病发病率的增加。本研究提示烟酒嗜好与无烟酒嗜好者Hp检出率的差异主要由吸烟所致。 【关键词】 吸烟；饮酒；幽门螺旋杆菌 Infects of smoking and alcohol consumption in gastric diseases with Helicobacter pylori infection 【Abstract】 Objective Research infects of smoking and alcohol’s in gastric diseases with H.pylori infection.Methods We random sampled those who come to have a gastroscope examination. By rapid urease test and histological analyzing, H.phlory infection is confirmed. Smoking and alcohol statistic data is acquired by paper questionnaire.Results Among 2186 cases, the Hp detectable rate of the 630 smokers is 55.7%, and the 1556 non-smokers 44.7%,difference between smoker and non-smoker is significant (Plt;0.05). the Hp detectable rate of the 322 alcohol?s is 54.3%, the 1864 non-alcohol?s 45.7%, the difference is not significant (Pgt;0.05). Among the 284 alcohol?s smoker, 62.32% was Hp infected. Among 1538 non-smoker and non-alcohol?s, 46.62% was Hp infected, the difference is signficant.Conclusion Smoking can increase the possibility of Hp infection and gastric diseases. The study show that Hp infection rate signficant difference between the alcohol’s smoker and the non-smoker and non-alcohol’s is resulted from smoking mainly. 【Key words】 smoking;alcohol consumption;helicobacter;pylori 幽门螺旋杆菌(Helicobacter pylori,Hp)是慢性胃炎、消化性溃疡、胃癌的主要致病因子之一。笔者对在本院胃镜检查的2186例患者中检测Hp感染并探讨其与吸烟、饮酒的关系报告如下。 1 对象与方法 1.1 观察对象 收集本院胃镜检查患者2186例（慢性胃炎1340例，消化性溃疡763例，胃癌71例，胃息肉12例），男1190例，女996例，平均年龄46.12±13.47岁；其中烟酒均嗜好者284例，无烟酒嗜好者1538例；所有患者在检查前均未接受抗Hp治疗。 1.2 方法 对来院作胃镜检查的患者用随机采样方式，Hp采用快速尿素酶试验与组织学检测，两者均为阳性者确定为Hp感染。在胃镜检查前采用问卷方式决定患者饮酒和吸烟情况。根据世界卫生组织关于吸烟的定义，将“一生中连续或累积吸烟6个月或以上者”定为吸烟者［1］。饮酒的标准定义为每周饮酒至少2次，