苦荞壳提取物对大鼠血脂调节作用.docVIP

苦荞壳提取物对大鼠血脂调节作用 　 作者：童红莉，田亚平，汪德清，董振南，邓心新 【关键词】 苦荞 　　Role of tartarian buckwheat shell extract in regulation of blood lipid in rats with hyperlipidemia 　　【Abstract】 AIM: To investigate the antihyperlipidemia effect of tartarian buckwheat shell extract (TBSE) in rats and its mechanism. METHODS: Fifty male Wistar rats were randomly separated into 5 groups according to body weight. They were fed respectively with normal diet, high lipid diet, high lipid diet supplemented with different concentrations of TBSE (0.825, 0.165 g/kg), high lipid diet supplemented with Lipingzhi capsules (LPZ, 0.067 g/kg). After 12 weeks, the concentrations of serum Ch, Tg, HDLC, LDLC, MDA, the activity of SOD and GPX, liver index were measured. RESULTS: Compared with those in normal diet group, the serum Ch, Tg, LDLC, MDA and liver index in high lipid diet group increased significantly (Plt;0.05), the serum HDLC and SOD decreased significantly (Plt;0.05). The serum GPX activity decreased and the body weight increased, but there was no significant statistical difference (Pgt;0.05). In LPZ group, compared with those in high lipid diet group, the serum Ch, Tg, LDLC and MDA decreased significantly (Plt;0.05), the serum GPX activity increased significantly (Plt;0.05), but the serum HDLC, SOD, body weight and liver index had no significant statistical changes (Pgt;0.05). Compared with those in high lipid diet group, the serum Ch, Tg, LDLC, MDA and liver index in TBSE group decreased significantly (Plt;0.05), the serum GPX and SOD activity increased significantly (Plt;0.05). The serum HDLC increased and the body weight decreased but there was no significant statistical difference (Pgt;0.05). CONCLUSION: TBSE can reduce the blood lipid and liver index and enhance the blood antioxidant activity in rats with hyperlipidemia, which can protect the normal tissues against the injury induced by high lipid diet. 　　【Keywords】 tartarian buckwheat shell extract; hyperlipidemia; disease models, animal; rats; blo