原创力文档acute pericarditis due to pegylated interferon alpha therapy for chronic hcv hepatitis - case report急性心包炎由于聚乙二醇干扰素α治疗慢性丙肝病毒肝炎u2014u2014病例报告.pdfVIP
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acute pericarditis due to pegylated interferon alpha therapy for chronic hcv hepatitis - case report急性心包炎由于聚乙二醇干扰素α治疗慢性丙肝病毒肝炎u2014u2014病例报告
Popescu et al. BMC Gastroenterology 2011, 11:30
/1471-230X/11/30
CASE REPORT Open Access
Acute pericarditis due to pegylated interferon alpha
therapy for chronic HCV hepatitis - Case report
*
Cristina Popescu , Victoria Arama and Smaranda Gliga
Abstract
Background: Cardio toxicity due to interferon therapy was reported only in small case series or case reports. The
most frequent cardiac adverse effects related to interferon are arrhythmias and ischemic manifestations. The
cardiomyopathy and pericarditis are rare but can be life threatening. The predisposing factors for interferon cardio
toxicity were described only for ischemic manifestations and arrhythmias.
Case presentation: The authors report a case of pericarditis due to alpha interferon therapy for chronic hepatitis
C, in a young woman without previous cardiac pathology. The clinical manifestations started during the 7-th
month of interferon treatment. The cessation of interferon was necessary. After interferon discontinuation the
patient recovered, with complete resolution of pericarditis. The patient scored 9 points on the Naranjo ADR
probability scale, indicating a very probable association between pericarditis and interferon administration.
Conclusion: If a patient receiving interferon therapy complains of chest pain of sudden onset, a cardiac ultrasound
should be performed in order to rule out pericarditis. We point out the possibility of an infrequent but severe
adverse effect of interferon therapy.
Background (180 μg weekly) and ribavirin (1000 mg daily, according
Pegylated interferon plus ribavirin represents the gold to her body weight). The patient had complete early
standard therapy for hepatitis C virus (HCV) but various vi
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