原创力文档hormonal status in protracted critical illness and in-hospital mortality激素状态在旷日持久的关键疾病和住院死亡率.pdfVIP
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hormonal status in protracted critical illness and in-hospital mortality激素状态在旷日持久的关键疾病和住院死亡率
Sharshar et al. Critical Care 2011, 15:R47
/content/15/1/R47
RESEARCH Open Access
Hormonal status in protracted critical illness and
in-hospital mortality
1* 2 1 3 4 1
Tarek Sharshar , Sylvie Bastuji-Garin , Andrea Polito , Bernard De Jonghe , Robert D Stevens , Virginie Maxime ,
5 6 3 7 8
Pablo Rodriguez , Charles Cerf , Hervé Outin , Philippe Touraine , Kathleen Laborde ,
the Groupe de Réflexion et d’Etude des Neuromyopathies En Réanimation
Abstract
Introduction: The aim of this study was to determine the relationship between hormonal status and mortality in
patients with protracted critical illness.
Methods: We conducted a prospective observational study in four medical and surgical intensive care units (ICUs).
ICU patients who regained consciousness after 7 days of mechanical ventilation were included. Plasma levels of
insulin-like growth factor 1 (IGF-1), prolactin, thyroid-stimulating hormone, follicle-stimulating hormone, luteinizing
hormone, estradiol, progesterone, testosterone, dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate
(DHEAS) and cortisol were measured on the first day patients were awake and cooperative (day 1). Mean blood
glucose from admission to day 1 was calculated.
Results: We studied 102 patients: 65 men and 37 women (29 of the women were postmenopausal). Twenty-four
patients (24%) died in the hospital. The IGF-1 levels were higher and the cortisol levels were lower in survivors.
Mean blood glucose was lower in women who survived, and DHEA and DHEAS were higher in men who survived.
Conclusions: These results suggest that, on the basis of sex, s
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