ingredient consistency of commercially available polyphenol and tocopherol nutraceuticals商用多酚成分的一致性和生育酚保健品.pdfVIP

Pharmaceutics 2010, 2, 50-60; doi:10.3390/pharmaceutics2010050 OPEN ACCESS pharmaceutics ISSN 1999-4923 /journal/pharmaceutics Article Ingredient Consistency of Commercially Available Polyphenol and Tocopherol Nutraceuticals Connie M. Remsberg, Renee L. Good and Neal M. Davies * Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Pullman, WA 99164-6534, USA; E-Mails: connie.remsberg@ (C.M.R.); renee.good@ (R.L.G.) * Author to whom correspondence should be addressed; E-Mail: ndavies@; Tel.: +1 509 335 4754; Fax: +1 509 335 5902. Received: 28 January 2010; in revised form: 3 March 2010 / Accepted: 4 March 2010 / Published: 8 March 2010 Abstract: Label claims of vitamin E succinate and polyphenolic nutraceuticals are assessed. A validated HPLC method was utilized to assess vitamin E succinate products. Three novel LC/MS methods were used to assess the polyphenols, pterostilbene, phloretin, and myricetin, in dietary supplements. The amount of vitamin E succinate varied from 0-130% of the stated label content with two products containing vitamin E acetate rather than vitamin E succinate. Expected polyphenols were found in 7 of the 8 supplement products. None of the polyphenol supplements contained content within 100-120% of label claims. The present study indicates a lack of uniformity in nutraceutical products. Keywords: content analysis; polyphenols; nutraceuticals; vitamin E succinate; pterostilbene; phloretin; myricetin 1