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norethindrone acetate in the medical management of adenomyosis子宫内膜异位的醋酸炔诺酮的医疗管理
Pharmaceuticals 2012, 5, 1120-1127; doi:10.3390/ph5101120
OPEN ACCESS
pharmaceuticals
ISSN 1424-8247
/journal/pharmaceuticals
Article
Norethindrone Acetate in the Medical Management of
Adenomyosis
1,2, 1 1 1
Ozgul Muneyyirci-Delale *, Ashadeep Chandrareddy , Siddhi Mankame , Nanna Osei-Tutu
3
and Hans von Gizycki
1 Department of Obstetrics and Gynecology, SUNY Downstate Medical Center, 450 Clarkson
Avenue, Brooklyn, NY 11203, USA
2 Department of Obstetrics and Gynecology, Kings County Hospital Center, 451 Clarkson Avenue,
Brooklyn, NY 11203, USA
3 Scientific Computing Center, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn,
NY 11203, USA
* Author to whom correspondence should be addressed; E-Mail: ozgul.muneyyircidelale@.
Received: 8 July 2012; in revised form: 4 October 2012 / Accepted: 15 October 2012 /
Published: 22 October 2012
Abstract: The role of norethindrone acetate (NA) in the management of adenomyosis was
evaluated with a retrospective chart review of 28 premenopausal women between 27–49 years
of age presenting with moderate to severe pelvic pain and bleeding. Bleeding and
dysmenorrhea scores were analyzed using paired T-tests. There was significant
improvement of both dysmenorrhea and bleeding after treatment. Age showed no
correlation with dysmenorrhea or bleeding. Low dose NA could be
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