omentin as a novel biomarker of metabolic risk factorsomentin作为新型生物标志物代谢危险因素.pdfVIP

Shibata et al. Diabetology Metabolic Syndrome 2012, 4:37 DIABETOLOGY /content/4/1/37 METABOLIC SYNDROME SHORT REPORT Open Access Omentin as a novel biomarker of metabolic risk factors 1 2* 3 1 2 3 4 Rei Shibata , Noriyuki Ouchi , Ryotaro Takahashi , Yuya Terakura , Koji Ohashi , Nobuo Ikeda , Akiko Higuchi , 5 5 1 Hiroko Terasaki , Shinji Kihara and Toyoaki Murohara Abstract Background: Omentin is an adipocytokine that is abundantly expressed in visceral fat tissue. We investigated the association of omentin with the number of metabolic risk factors. Finding: The study population comprised 201 Japanese men who underwent annual health checkups. Plasma omentin levels were determined by enzyme-linked immunosorbent assay. We divided the subjects into 4 groups according to omentin levels. A reduction of plasma omentin levels significantly correlated with an increase in the mean number of metabolic risk factors such as increased waist circumference, dyslipidemia, high blood pressure and glucose intolerance. Conclusions: Circulating omentin levels negatively correlated with the multiplicity of metabolic risk factors, suggesting that omentin acts as a biomarker of metabolic disorders. Keywords: Omentin, Adipocytokine, Metabolic disorders, Risk factors, Biomarkers Findings Omentin/intelectin-1 is an adipocytokine that exists in Obesity has becom