pharmacokinetic drug interactions of antimicrobial drugs a systematic review on oxazolidinones, rifamycines, macrolides, fluoroquinolones, and beta-lactams抗菌药物的药代动力学的药物相互作用系统回顾oxazolidinones、利福霉素、大环内酯类、氟喹诺酮类原料药和beta-lactams.pdfVIP

Pharmaceutics 2011, 3, 865-913; doi:10.3390/pharmaceutics3040865 OPEN ACCESS Pharmaceutics ISSN 1999-4923 /journal/pharmaceutics Review Pharmacokinetic Drug Interactions of Antimicrobial Drugs: A Systematic Review on Oxazolidinones, Rifamycines, Macrolides, Fluoroquinolones, and Beta-Lactams Mathieu S. Bolhuis *, Prashant N. Panday, Arianna D. Pranger, Jos G. W. Kosterink and Jan-Willem C. Alffenaar Department of Hospital and Clinical Pharmacy, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands; E-Mails: p.n.panday@umcg.nl (P.N.P.); a.pranger@umcg.nl (A.D.P.); j.g.w.kosterink@umcg.nl (J.G.W.K.); j.w.c.alffenaar@umcg.nl (J.-W.C.A.) * Author to whom correspondence should be addressed; E-Mail: m.s.bolhuis@umcg.nl; Tel.: +31-50-361-4071; Fax: +31-50-361-4078 Received: 15 October 2011; in revised form: 26 October 2011 / Accepted: 9 November 2011 / Published: 18 November 2011 Abstract: Like any other drug, antimicrobial drugs are prone to pharmacokinetic drug interactions. These drug interactions are a major concern in clinical practice as they may have an effect on efficacy and toxicity. This article provides an overview of all published pharmacokinetic studies on drug interactions of the commonly prescribed antimicrobial drugs oxazolidinones, rifamycines, macrolides, fluoroquinolones, and beta-lactams, focusing on systematic research. We describe drug-food and drug-drug interaction studies in humans, affecting antimicrobial drugs as well a