原创力文档ricinus communis intoxications in human and veterinary medicine—a summary of real cases萝藦中毒在人类和兽医医学总结的情况.pdfVIP
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ricinus communis intoxications in human and veterinary medicine—a summary of real cases萝藦中毒在人类和兽医医学总结的情况
Toxins 2011, 3, 1332-1372; doi:10.3390/toxins3101332
OPEN ACCESS
toxins
ISSN 2072-6651
/journal/toxins
Review
Ricinus communis Intoxications in Human and Veterinary
Medicine—A Summary of Real Cases
Sylvia Worbs 1, Kernt Köhler 2, Diana Pauly 1, Marc-André Avondet 3, Martin Schaer 3,
Martin B. Dorner 1 and Brigitte G. Dorner 1,*
1 Centre for Biological Security, Microbial Toxins (ZBS3), Robert Koch-Institut, Nordufer 20, Berlin
13353, Germany; E-Mails: worbss@rki.de (S.W.); paulyd@rki.de (D.P.); dornerm@rki.de (M.B.D.)
2 Institute of Veterinary Pathology, Justus Liebig University Giessen, Frankfurter Street 96,
Giessen 35392, Germany; E-Mail: Kernt.Koehler@vetmed.uni-giessen.de
3 Biology and Chemistry Section, Federal Department of Defence, Civil Protection and Sports DDPS
SPIEZ LABORATORY, Austrasse 1, Spiez CH-3700, Switzerland;
E-Mails: marc.avondet@babs.admin.ch (M.-A.A.); Martin.Schaer@babs.admin.ch (M.S.)
* Author to whom correspondence should be addressed; E-Mail: dornerb@rki.de;
Tel.: +49-30-18754-2500; Fax: +49-30-18754-2501.
Received: 15 August 2011; in revised form: 26 September 2011 / Accepted: 30 September 2011 /
Published: 24 October 2011
Abstract: Accidental and intended Ricinus communis intoxications in humans and animals
have been known for centuries but the causative agent remained elusive until 1888 when
Stillmark attributed the toxicity to the lectin ricin. Ricinus communis is grown worldwide
on an industrial scale for the production of castor oil. As by-product in castor oil
pro
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