原创力文档the ehec type iii effector nlel is an e3 ubiquitin ligase that modulates pedestal formation肠出血性大肠杆菌感染类型iii效应nlel是一个调节底座的e3泛素连接酶的形成.pdfVIP
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the ehec type iii effector nlel is an e3 ubiquitin ligase that modulates pedestal formation肠出血性大肠杆菌感染类型iii效应nlel是一个调节底座的e3泛素连接酶的形成
The EHEC Type III Effector NleL Is an E3 Ubiquitin Ligase
That Modulates Pedestal Formation
1 1 2¤ 2
Heather Piscatelli , Shalaka A. Kotkar , Megan E. McBee , Sureshkumar Muthupalani , David B.
2 3 4 1
Schauer , Robert E. Mandrell , John M. Leong , Daoguo Zhou *
1 Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America, 2 Department of Biological Engineering and Comparative
Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, 3 Agricultural Research Service, United States Department of
Agriculture, Albany, California, United States of America, 4 Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester,
Massachusetts, United States of America
Abstract
Enterohemorrhagic Escherichia coli (EHEC) O157:H7 causes hemorrhagic colitis and may result in potentially fatal hemolytic
uremia syndrome in humans. EHEC colonize the intestinal mucosa and promote the formation of actin-rich pedestals via
translocated type III effectors. Two EHEC type III secreted effectors, Tir and EspFu/TccP, are key players for pedestal
formation. We discovered that an EHEC effector protein called Non-LEE-encoded Ligase (NleL) is an E3 ubiquitin ligase. In
vitro, we showed that the NleL C753 residue is critical for its E3 ligase activity. Functionally, we demonstrated that NleL E3
ubiquitin ligase activity is involved in modulating Tir-mediated pedestal formation. Surprisingly, EHEC mutant strain
deficient in the E3 ligase activity induced more
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