原创力文档use of multiplex allele-specific polymerase chain reaction (mas-pcr) to detect multidrug-resistant tuberculosis in panama使用多路复用allele-specific聚合酶链反应(mas-pcr)检测在巴拿马耐多药结核病.pdfVIP
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use of multiplex allele-specific polymerase chain reaction (mas-pcr) to detect multidrug-resistant tuberculosis in panama使用多路复用allele-specific聚合酶链反应(mas-pcr)检测在巴拿马耐多药结核病
Use of Multiplex Allele-Specific Polymerase Chain
Reaction (MAS-PCR) to Detect Multidrug-Resistant
Tuberculosis in Panama
1. 2. 1 1 3 1
Bing-Shao Chia , Fedora Lanzas , Dalin Rifat , Aubrey Herrera , Elizabeth Y. Kim , Christine Sailer ,
1 4 4 2 2
Edith Torres-Chavolla , Purvaja Narayanaswamy , Viktor Einarsson , Jaime Bravo , Juan M. Pascale ,
4 5 1,3
Thomas R. Ioerger , James C. Sacchettini , Petros C. Karakousis *
1 Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, 2 Department of Genomics and Proteomics,
´ ´ ´
Instituto Conmemorativo Gorgas de Estudios de la Salud, ICGES, Panama, Republica de Panama, 3 Department of International Health, Johns Hopkins Bloomberg School
of Public Health, Baltimore, Maryland, United States of America, 4 Department of Computer Science, Texas AM University, College Station, Texas, United States of
America, 5 Department of Biochemistry/Biophysics, Texas AM University, College Station, Texas, United States of America
Abstract
The frequency of individual genetic mutations conferring drug resistance (DR) to Mycobacterium tuberculosis has not been
studied previously in Central America, the place of origin of many immigrants to the United States. The current gold
standard for detecting multidrug-resistant tuberculosis (MDR-TB) is phenotypi
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