辛伐他汀对肾移植后高脂血症患者RANTES及其受体CCR5 mRNA表达影响.docVIP

下载本文档

2
0
约 8页
2017-09-12 发布于福建
举报
版权申诉

辛伐他汀对肾移植后高脂血症患者RANTES及其受体CCR5 mRNA表达影响.doc

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

辛伐他汀对肾移植后高脂血症患者RANTES及其受体CCR5 mRNA表达影响

辛伐他汀对肾移植后高脂血症患者RANTES及其受体CCR5 mRNA表达影响　作者：史艳玲, 邹和群, 王玉新, 徐琴君, 唐孝达【关键词】; ,肾移植 ; Effect of simvastatin on expression of RANTES and its receptor CCR5 mRNA in renal transplant recipients with hyperlipidemia　　【Abstract】 AIM: To study whether hyperlipidemia after renal transplantation is related to the expression of RANTES (regulated on activation normal Tcell expressed and secreted) and its receptor CCR5 (chemokine receptor 5) mRNA in peripheral monocyte cells (PMCs) and to explore its therapy. METHODS:; Renal recipients were divided into normal lipidemia group (n=30) and hyperlipidemia group (n=30) according to the serum lipid level 6-8 months after transplantation. The patients in the hyperlipidemia group were treated with simvastatin for 1.5 months (1.5month treatment group) or 3 months (3month treatment group). The control group consisted of 30 healthy subjects. Serum total cholesterol (TC), triglyceride (TG), lowdensity lipoprotein (LDL), highdensity lipoprotein (HDL) were measured and RTPCR was used to detect the expression of RANTES and CCR5 mRNA in PMCs. RESULTS:; The renal function of all the patients was normal. TC, TG, LDL and expression of RANTES and CCR5 mRNA in the normal lipidemia group were lower than those in the hyperlipidemia group, but higher than those in control group (Plt;0.05), and those in 3month treatment group were significantly lower than those in 1.5month treatment group (Plt;0.05). CONCLUSION:; The expression of RANTES and CCR5 mRNA is involved in the earlystage chronic injury of kidney allografts. Hyperlipidemia can strengthen the increased expression of RANTES and CCR5 mRNA. Simvastatin can reduce the expression of RANTES and CCR5 mRNA in the kidney transplant recipients with hyperlipidemia.　　【Keywords】 kidney transplantation；hyperlipidemia；RANTES；RTPCR；simvastatin　　【摘要】目的: 探讨肾移植术后高脂血症患者外周血RANTES (regulated on activation normal Tcell expressed and secreted)及其受体CCR5(chemokine receptor 5) mRNA表达及治疗. 方法: 根据患者肾移植术后6~8 mo的血脂水平分血脂正常组（n=30）