复合振动仪治疗骨质疏松对骨代谢影响临床观察.docVIP

复合振动仪治疗骨质疏松对骨代谢影响临床观察 　 作者：郑锦畅 陈建庭 裴卫卫 【摘要】 目的 观察复合振动仪治疗骨质疏松(OP)对骨代谢的影响。方法 70例OP志愿者随机分成复合振动组和对照组，每组35例。复合振动组采用自行研制的复合振动仪进行全身振动治疗，振动频率45～55 Hz，振动强度0.5～0.8 g，1次/隔天，30 min/次，连续3个月，对照组不进行任何干预，于试验开始前3天、试验后第1、3个月分别检测各组碱性磷酸酶(ALP)、骨钙素(OC)、抗酒石酸酸性磷酸酶(TRAP)、钙磷乘积(〔Ca〕×〔P〕)的变化。结果 第3个月，复合振动组的ALP、OC、TRAP、〔Ca〕×〔P〕分别比试验前增加了44.6%、-9.4%、1.7%、7.5%，对照组的相应指标分别比试验前增加了22.8%、-13.3%、3.6%、4.7%，P值分别为0.108、0.788、0.606、0.171。结论 复合振动仪治疗OP对骨代谢的影响无统计学意义，但骨代谢的绝对值有变化。 【关键词】 复合振动;骨质疏松;碱性磷酸酶;骨钙素;抗酒石酸酸性磷酸酶;钙磷乘积 Clinical observation of bone metabolism in osteoporosis patients treated with compound vibration machine 　　ZHENG JinChang, CHEN JianTing, PEI WeiWei. 　　Department of Orthopaedic Surgery and Spine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, China 　　【Abstract】 Objective To observe the effect of bone metabolism in osteoporosis (OP) patients treated with compound vibration machine. Methods 70 OP volunteers were selected and were randomly divided into whole body compound vibration training group (WBCV, n=35) and control group (CON, n=35). The patients in WBCV group treated with 3month whole body compound vibration (30 min/d, 1 time/qd, oscillation frequency 45～55 Hz, intensity of vibration 0.5～0.8 g). The patients in CON group weren′t given any treatment, did not participate in any training, just keeping the normal life as before. Alkaline phosphatase (ALP), osteocalcin(OC), tartrateresistance acid phosphatase (TRAP) and calciumphosphorus product were measured on 3 days before experiment, 1 and 3 months after experiment. Results The level of ALP, OC, TRAP, 〔Ca〕×〔P〕 in WBCV group was increased by 44.6%, -9.4%, 1.7% and 7.5% respectively. However, it was increase by 22.8%, -13.3%, 3.6% and 4.7% respectively in CON group(P=0.108, 0.788, 0.606 and 0.171). Conclusions The whole body compound vibration training has no effect on bone metabolism in OP, while the absolute value of bone metabolism has been changed. 　　【Key words】 Compound vibration; Osteoporosis; Alkaline